Manufacturer-Hydroxypropyl beta cyclodextrin CAS NO.128446-35-5

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Hydroxypropyl beta cyclodextrin CAS:128446-35-5. 
Formula number: F20190001935 oral, F20190001934 injection. 
HP- β-CD), is a hydroxyalkylated derivative of beta-cyclodextrin (β-CD).Hydroxypropyl beta cyclodextrin is non-toxic and has no side effects. because of the particularity of its structure, it can greatly improve the solubility of insoluble drugs and make insoluble or insoluble drugs soluble in water. Therefore, it can effectively improve the bioavailability of drugs, can greatly improve drug quality and dosage forms, and is widely used in the development and production of new drugs. 
The properties, preparation technology, stability, pharmacology, toxicology, teratogenicity, mutagenicity, carcinogenicity, hemolysis and irritation of hydroxypropyl beta cyclodextrin have been deeply studied in the world, and its safety has been accurately evaluated. It can be said that at present, it is a valuable medicinal excipient in cyclodextrin derivatives with extensive study of zui, in-depth zui, comprehensive data zui and valuable zui in medicine. 
The introduction of hydroxypropyl breaks the intramolecular cyclic hydrogen bond of betacyclodextrin and overcomes the main disadvantage of poor water solubility of betacyclodextrin while keeping the cavity of cyclodextrin. At present, it is one of the cyclodextrin derivatives which are deeply studied in zui and widely used in zui. Mainly used in food, medicine, cosmetics industry. 
1. In the pharmaceutical industry: because the relative surface activity and hemolytic activity are relatively low and have no irritation to muscle, hydroxypropyl betacyclodextrin is an ideal injection solubilizer and drug excipient. It can improve the water solubility of insoluble drugs, increase the stability of drugs, improve the bioavailability of drugs, increase the efficacy or reduce the dosage of drugs, adjust or control the release rate of drugs, and reduce the side effects of drugs. It can be used in oral drug, injection, mucosal drug delivery system (including nasal mucosa, rectum, cornea, etc.), transdermal absorption drug delivery system, lipophilic targeted drug carrier, protein protector and stabilizer. 
2. In the field of food and spices: hydroxypropyl beta cyclodextrin can improve the stability and long-term effect of nutritional molecules, cover up or correct the bad smell and taste of food nutritional molecules, and improve the production process and product quality.The product has good solubility in water, and the degree of substitution of 4 or more can be miscible with water in any proportion, and it can also be dissolved in 50% ethanol and methanol. 
3. In the field of cosmetic raw materials: hydroxypropyl beta cyclodextrin is used as stabilizer, emulsifier, deodorant, etc., which can reduce the stimulation of organic molecules in cosmetics to skin and mucous membrane, enhance the stability of effective components, and prevent the volatilization and oxidation of nutrients. It has a certain relative hygroscopicity.